منابع مشابه
SnapShot: Origins of DNA Replication
The fundamental unit of DNA replication, the replicon, is governed by a cis-acting replicator sequence and a trans-activating initiator factor. Despite the increased size and complexity of eukaryotic genomes, eukaryotic DNA replication continues to be guided by the fundamental principles and concepts established in the replicon model.
متن کاملDNA replication origins in archaea
DNA replication initiation, which starts at specific chromosomal site (known as replication origins), is the key regulatory stage of chromosome replication. Archaea, the third domain of life, use a single or multiple origin(s) to initiate replication of their circular chromosomes. The basic structure of replication origins is conserved among archaea, typically including an AT-rich unwinding reg...
متن کاملOptimal placement of origins for DNA replication.
DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, called origins, and the subsequent activation of proteins lead to variations in the replication time. We analyze these stochastic properties of DNA and derive the positions of origins corresponding to the minimum...
متن کاملDNA replication: the unbearable lightness of origins.
Now that the genomes of various metazoans have been sequenced, one of the biggest challenges in biology is to understand their functional organization. Programmed alterations of gene expression during development and cell differentiation frequently involve long-range modifications in the organization of chromosomal loci. These modifications include nuclear localization, genetic locus conformati...
متن کاملMaking sense of eukaryotic DNA replication origins.
DNA replication is the process by which cells make one complete copy of their genetic information before cell division. In bacteria, readily identifiable DNA sequences constitute the start sites or origins of DNA replication. In eukaryotes, replication origins have been difficult to identify. In some systems, any DNA sequence can promote replication, but other systems require specific DNA seque...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2013
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a010116